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Clinical Trial facts

While investigating facts about Clinical Trials and Clinical Trial Phases, I found out little known, but curios details like:

Around half of all clinical trials by drug companies go unpublished. Which leads to overestimation of drug efficiency and an underestimation of dangers. And that a movement called AllTrials, which is supported by hundreds of organisations, has been fighting for all trials to be released.

how clinical trials work?

In a review of clinical drug trials, almost all negative studies were unpublished, leading to the false impression that 93% of antidepressant trials had positive results. When unpublished studies were included, 51% of all clinical trials were positive and 49% were negative.

What is phase 3 clinical trial?

In my opinion, it is useful to put together a list of the most interesting details from trusted sources that I've come across answering what is a phase 2 clinical trial. Here are 50 of the best facts about Clinical Trials Near Me and Clinical Trial Definition I managed to collect.

what's clinical trials?

  1. Eli Lilly, the company behind the SSRI antidepressant Prozac, hid its clinical trials from the FDA that showed patients who took Prozac were 12 times more likely to commit suicide compared to older antidepressants.

  2. A clinical trial in 2016 held at Stanford University School of Medicine found that injecting modified human stem cells directly into the brains of chronic stroke patients can re-enable patients to walk.

  3. Traci Johnson, a healthy 19-year-old college student volunteer enrolled in a clinical trial for the antidepressant Cymbalta and shortly after hung herself at the testing facility.

  4. The FDA approved the first gene therapy drug for use in the US - the drug modifies patient T-cells to hunt down and destroy cancer cells and has produced very high response and remission rates in clinical trials.

  5. The Sinclair Method is 80% effective in 90 clinical trials at treating alcohol addiction, much more effective in the long term to the 12 Step Method from AA.

  6. A 26 year old male tried to commit suicide by swallowing 29 pills that he had recieved during a clinical trial. He was rushed to the hospital and was seemingly about to die from the side effects until he learned he had recieved placebo

  7. Bayer's testing group rejected Aspirin for clinical trials because of its potential to "weaken the heart" and instead decided to pursue developing heroin.

  8. Prior to 1993 the FDA banned women from participating in clinical trials. This resulted in a dangerous lack of awareness about how certain drugs impacted women and has led to misunderstandings about how certain diseases affect men and women differently that persist today.

  9. 95% of the drugs thought to be promising after experiments on mice, fail when subjected to clinical trials.

  10. Groundbreaking new cancer therapies ramp up the body's own immune system to eradicate cancer cells. One promising immunotherapy method, known as CAR T, has shown incredible success in clinical trials with children when most other options have failed.

clinical trial facts
What are the phases of clinical trials?

Clinical Trial data charts

For your convenience take a look at Clinical Trial figures with stats and charts presented as graphic.

clinical trial fact data chart about Clinical Trials Landscape in Minneapolis, Minnesota
Clinical Trials Landscape in Minneapolis, Minnesota

clinical trial fact data chart about Clinical Trials Landscape in Raleigh, North Carolina
Clinical Trials Landscape in Raleigh, North Carolina

Why clinical trials?

You can easily fact check why participate in clinical trials by examining the linked well-known sources.

The first birth control pill used Puerto Rican women as guinea pigs for their clinical trials.

Only 17% of paid clinical trials in the US had their results published in the time required by law. Not publishing all trials allows drug makers to hide unflattering results, and helps medicines look safer and more effective than they really are. - source

The Chinese Government Found That More Than 80% Of The Data Used In Clinical Trials Of New Pharmaceutical Drugs Have Been "Fabricated", And That The Behavior Persists At Almost Every Level - source

The drug Viagra was developed to lower blood pressure, with its main current use being discovered as a "side effect" in clinical trials.

There has never been a double-blind placebo-controlled clinical trial measuring the benefits of lowering a fever when patients have influenza, and some research indicates fever reducers can make illness more severe. - source

When clinical trials gone wrong?

The findings of world's largest antidepressant trial which showed an avg improvement of 6.6 points on HRSD which is less than placebo & falls below the threshold of 7 on CGI scale which corresponds to 'minimally improved’ suggesting clinical trials grossly overestimate antidepressant efficacy

How long do clinical trials take?

Oxycyte can carry five times more oxygen than hemoglobin but it is not a complete blood substitute and it is still in clinical trials.

Craniosacral therapy (CST), a way of manipulating the synarthrodial joints of the cranium. Practitioners believe that this regulates the flow of cerebrospinal fluid and aids in "primary respiration". A systematic review of randomized clinical trials concluded it "is bogus".

Around half of the clinical trials done on medicines we use today are not published

About MK-677, an investigational new drug known as a GH secretagogue that can be taken orally and has been shown to significantly increase basal metabolic rate and fat free mass in obese human subjects with little to no side effects in several clinical trials.

A study that looked at both published and unpublished clinical trial data concluded that Paxil offers only a slight benefit over placebo for treating anxiety and depression

Clinical trial infographics

Beautiful visual representation of Clinical Trial numbers and stats to get perspecive of the whole story.

clinical trial fact infographic about Clinical Trials Landscape in Atlanta, Georgia

Clinical Trials Landscape in Atlanta, Georgia


clinical trial fact infographic about Clinical Trials Landscape in Houston, Texas

Clinical Trials Landscape in Houston, Texas


When does derek forgive meredith for the clinical trial?

The difference between drug efficacy and drug effectiveness. Efficacy refers to results from controlled, clinical trials, while effectiveness refers to real-world results of the drug.

The mean improvement in depression for SSRIs (antidepressants) against placebo in the initial published and unpublished clinical trials was less than two points. The National Institute for Health and Care Excellence (NICE) in the UK defines clinical significance as a minimum of three points.

A US psychologist ran a clinical trial into the benefits of MDMA use to combat PTSD and found that 10 of the 12 test users no longer qualified as sufferers of PTSD. An Army Major was then put under treatment and his PTSD rapidly declined in severity too

A review of clinical trials showed that counselling provides short-term, modest improvements in reducing anxiety and depression, but no long-term improvements. Another review showed that it didn't have an impact on patients’ social functioning, such as work, leisure, &family relationships.

Pharmaceutical Companies Cherry-Pick Positive Results-Clinical trial data on new drugs is systematically withheld from doctors and patients, bringing into question many of the premises of the pharmaceutical industry—and the medicine we use

How do clinical trials work?

Botox is in clinical trials for the treatment of severe Premature Ejaculation

A 26 year old male tried to commit suicide by swallowing 29 pills that he had recieved during a clinical trial. He was rushed to the hospital and was seemingly about to die from the side effects until he learned he had recieved placebo.

In 1994 a clinical trial was conducted that studied how many times a group of 19 test subjects farted after eating meatless chili.

A 2010 study led by the Clinical Trial Service Unit at Oxford University found that a combination drug that lowers levels of ‘bad’ cholesterol in the blood can benefit people with chronic kidney disease.

Viagra, or Sildenafil, as it's officially known, was originally conceived as a treatment for hypertension, angina, and other symptoms of heart disease. But Phase I clinical trials revealed that male test subjects were experiencing a rather unexpected side effect: erections.

Laetrile (AKA Amygdalin/B17), was once developed as an anticancer drug. It was later proposed that the name be spelt 'liar-trial' since the results of the clinical trials on laetrile turned out to have been falsified.

Viagra was originally developed for high blood pressure, but volunteers in the clinical trials reported increased erections several days after taking a dose of the drug.

The University of Ottawa has begun clinical trials in treating depression with Ketamine, as it's been shown to immediately alleviate symptoms for several days.

The first controlled clinical trials on humans took place in 1749, and were a successful attempt to find a treatment for scurvy

Foregen is a Charity Pursuing Clinical Trials to Realize Genital Autonomy as an Option for All

In the past decade, over 99.6% of drugs entering clinical trials for the treatment of Alzheimer's Disease have failed. Of 244 compounds tested across 413 clinical trials, only one was approved.

Patient number 007 was the first to respond to the multiple myeloma drug, bortezomib, in clinical trials. His name was James Bond.

Early stage clinical research is considered ethical because, although there are usually no benefits for the individuals participating, benefits to society are taken into account when designing phase 1 trials

In the first ever human clinical trial, physician James Lind, who was trying to find a cure for scurvy, assigned one of the groups a treatment of sea water and another group received sulfuric acid.

The most common group of anti-depressants have no clinically significant benefit, but they increase the risk of serious adverse events, despite a high risk of bias in trials.

This is our collection of basic interesting facts about Clinical Trial. The fact lists are intended for research in school, for college students or just to feed your brain with new realities. Possible use cases are in quizzes, differences, riddles, homework facts legend, cover facts, and many more. Whatever your case, learn the truth of the matter why is Clinical Trial so important!

Editor Veselin Nedev Editor